Manchester United and Paris Saint-Germain will meet in the Champions League for the third time in four seasons after being paired together in Monday’s draw for the last 16.
PSG will be at home in the first leg in February in a tie that will see Lionel Messi and Cristiano Ronaldo come up against each other.
Atletico Madrid and Bayern Munich were drawn together in the other standout tie, while holders Chelsea will face French champions Lille.
Messi moved to Paris in August just before his old rival Ronaldo returned to Old Trafford for a second spell.
United famously beat PSG in the last 16 in 2018/19 at the start of Ole Gunnar Solskjaer’s reign as manager, recovering from a 2-0 loss at home in the first leg to win the return 3-1 and advance on away goals.
The clubs also met in the group stage last season, with the away side winning on each occasion.
Despite the signing of Messi, Mauricio Pochettino’s PSG finished second in their group this season behind Manchester City, while United topped Group F ahead of Villarreal.